![]() Deficiency and blockage of neurotrophic factors.Loss of motor neurons by genetic programs of microglial cells and astrocytes.It is known that two or more factors are involved in combination rather than a single factor that independently causes the disease. The following factors are known to be involved from case reports of patients. Sporadic factors Like other degenerative brain diseases, the cause of the disease is not clearly known. In addition, six other genetic mutations have been reported.It is located on the long arm of chromosome 9 (9q34) and is autosomal dominant, and characteristically occurs in the 20s age group.It is an autosomal recessive genetic trait (2q33), and ALS2 usually appears in the age range of 10-20 years and progresses slowly upto 10-15 years.The autosomal dominant gene type is caused by mutations in the Cu/Zn-superoxide dismutase (SOD1, 21q22.1) gene. It accounts for approximately 15-20% of hereditary amyotrophic lateral sclerosis cases.Genetic factors It is inherited as an autosomal dominant or recessive trait, and mainly occurs in adulthood in cases of autosomal dominant inheritance and in childhood or adolescence in cases of sex chromosomal recessive inheritance (juvenile onset). Sleep and arousal, yawning, avoidance responses to pain stimuli, and other lower brain tissue reactionsĪpart from genetic factors (10%), ALS is known to be associated with damage to motor nerves due to lifestyle and exposure to certain toxic substances, such as group outbreaks caused by specific regional or environmental factors.Not knowing the surroundings, unable to speak or voluntarily exercise.Difficulty recovering consciousness due to severe brain damage.Significant recovery can be achieved through active rehabilitation treatment. ![]()
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